Protein Details: Two pore calcium channel protein 1

Protein ID

ICDB_Pro_1123

Protein Name

Two pore calcium channel protein 1

Gene Name

TPC1

Organism

Triticum aestivum (Wheat)

Length

742 amino acids

AlphaFoldDB

AF-Q6YLX9-F1-model_v4.pdb

Function

Functions as a voltage-gated inward-rectifying Ca(2+) channel (VDCC) across the plasma membrane that mediates sucrose-induced Ca(2+) influx in autotrophically grown leaf cells. Acts as the major ROS-responsive Ca(2+) channel and is the possible target of Al-dependent inhibition. Plays a regulatory role in defense responses.

Sequence

MSEAEAPLITEEAAERGLASSGSRRLSDGAGGQGSRKYRRRSDALAYGDRYQKAAALVDLAEDGVGIPEDVLNDTRFGRAMSFYFVYLRLDWLWSLNLFALILLNFLEKPLWCRKDALQAYDQRDLYFLGQLPYFSKTESLIYEGLTLVILVMDIFCPLSYEGLNIFWRSTTNKLKIVLLFILACDILVFAFSSQPFRLAPYIRVVFLIMTIRELRMCAITLAGLIGTYLNVLALSLLFLLFASWLAYVTFEDTPQGKTIFSSYGVTLYQMFVLFTTSNNPDVWVHAYKIPRWYSLFFIVYVLLGVYFLTNLILAVIYDSFKEQFAKQLVQVDSIRKNILQKAFDLIDTNNRGYLDREQCISLLNELNKYRSLPKTSREDFELIFAELDRSGDFKVTSEEFADLCNTIAIKFQKEPPPSYLEKFPFYHSPLCGRLKSFVRSRMFEYIIVFVLLINLVAVIIETTLDIENSSSQETWQEVEFFLGWIYVAEMALKIFSLGFGAYWMEGQNKFDFVLTWTIFIGETLTFAFPSKLPFLSNGEWIRYLLLGRVLRLTRILLQVQRFRAFVATFFTLMSSLMPYLGIVFCVLCMYCSIGLQIFGGIVYAGNPTLEETDLFNNDYLLFNFNDYPSGMVTLFNLLVMGNWQVWMESYWQLTGTSWSLIYFVSFYLISILLLLNLIVAFVLEAFFAEMELEKGEEVDIQNPTSGGIKKRRSMRVRSKGTMVDILLHHMLSNELDGSQNS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1093/jxb/eri302

RefSeq

Feature